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Synthesis of the Chalcone 6 and the Dimer 8 of the 4-Ethyl Analogue 5fa
Competition curves of naltrexone (◼) and compounds 8 (△), 9 (▼), 10 (+), 12 (▲), 15 (◇), 31 (○) and 32 (●) for [3H]-DAmGO binding to Wistar rat forebrain membranes.
Biologically important molecules containing C3-functionalized oxindoles or a,b-unsaturated ketones, and the design strategy of combinatorial chemistry for new compound.
Synthesis of chalcones and pyrazoline derivatives (13a–e) in 50–70% yield, (14a–e) in 57–82% yield, 2-iminopyridine derivatives (15a–d) in 64–78% yield, and 2-oxopyridine derivatives (16a–d) in 62–71% yield.
