hydrochloride hydrate (CAS NO.: ), with other name of 2-Difluoromethyl-DL-ornithine monohydrochloride monohydrate, could be produced through the following synthetic routes.

The reaction routes are as below:

The optical resolution of 2,5-diamino-2-(difluoromethyl)pentanoic acid is performed as follows: The cyclization of its corresponding (I) by means of sodium methoxide in methanol gives the racemic piperidone (II), which is submitted to optical resolution with (-)-binaphthylphosphoric acid yielding after crystallization and acidification with HCl the (+) and (-) piperidones (III) and (IV). Finally, both compounds are treated with refluxing 6N HCl to afford the target enantiomers.