(CAS NO.: ), with its systematic name of acetamide, N-(aminoiminomethyl)-2,6-dichloro-, monohydrochloride, could be produced through many synthetic methods.

Following are some of the synthesis routes:

Method one:
1). By methanolysis of 2,6-dichlorophenylacetonitrile (I) in the presence of H₂SO₄ to methyl 2,6-dichlorophenylacetate (II), which is then condensed with guanidine (A) in isopropanol.
2). By condensation of S-methylisothiourea (V) with 2,6-dichlorophenylacetyl chloride (VI) in acetone to afford S-methyl-N-(2,6-dichlorophenylacetyl)isothiourea (VII); this product is then treated with ammonia in isopropanol.
3). By condensation of 2,6-dichlorophenylacetic acid (VIII) with guanidine (A) in toluene.

Method two:
The nitrile (I) could react with ethyl formate (B) in the presence of NaOEt in ethanol to produce alpha-formyl-2,6-dichlorophenylacetonitrile (III), which is condensed with guanidine hydrochloride (A) by means of NaOEt in ethanol to yield alpha-(guanidinomethylene)-2,6-dichlorophenylacetonitrile (IV); this product is finally hydrolyzed and rearranged by means of HCl.