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 Preparation of Dimethyl acetylenedicarboxylate
  • Preparation of Dimethyl acetylenedicarboxylate
  • Dimethyl dicarboxylate (CAS NO.: ), which is also known as , di, could be produced through the following synthetic routes.

    Preparation of Dimethyl acetylenedicarboxylate

    To 400 g. (510 ml., 12.5 moles) of methanol (commercial grade) in a 2-l. round-bottomed flask is added in small portions with cooling 200 g. (111 ml., 2.04 moles) of concentrated sulfuric acid. To this cooled solution is added 100 g. (0.66 mole) of the potassium acid salt of acetylenedicarboxylic acid. The flask is fitted with a stopper holding a calcium chloride drying tube and allowed to stand with occasional swirling for 4 days at room temperature.

    The liquid in the flask is then decanted from the inorganic salt, which is washed with 500 ml. of cold water. The solutions are combined and extracted with five 500-ml. portions of ether. The ether extracts are combined and washed successively with 200 ml. of cold water, 150 ml. of saturated sodium bicarbonate solution, and 200 ml. of cold water and then dried over anhydrous calcium chloride. After removal of the ether by distillation from a steam bath, the ester is distilled under reduced pressure from a modified Claisen flask. The yield of ester boiling at 95–98°/19 mm. is 67–82 g. (72–88%); nD25 1.4444–1.4452.


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