- Crotonic acid
- Crotonic Acid
- Crotonic Anhydride
- 62369-67-9Eicosane-1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,19,19,20,20,20-d42
- 623-69-82-Propanol,1,3-dimethoxy-
- 623-70-12-Butenoic acid, ethylester, (2E)-
- 623-71-2Propanoic acid,3-chloro-, ethyl ester
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- 623-76-7Urea, N,N'-diethyl-
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- 623-78-9Carbamic acid,N-ethyl-, ethyl ester
- 623-79-0Carbonodithioic acid,O,S-diethyl ester
- 62379-61-7MISCH METAL
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Cas Database |
| Name |
Crotonic Anhydride |
EINECS | 210-807-1 |
| CAS No. | 623-68-7 | Density | 1.038 g/cm3 |
| PSA | 43.37000 | LogP | 1.20840 |
| Solubility | N/A | Melting Point |
72oC |
| Formula | C8H10O3 | Boiling Point | 247 °C at 760 mmHg |
| Molecular Weight | 154.166 | Flash Point | 106.1 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 26-36/37/39-45 | Risk Codes | 34 |
| Molecular Structure |
|
Hazard Symbols |
 C
|
| Synonyms |
2-Butenoicacid, anhydride (9CI);Crotonic anhydride (6CI,7CI,8CI);2-Butenoic anhydride;Crotonic acid anhydride;NSC 97397;Crotonic Anhydride; |
Article Data | 24 |
Crotonic Anhydride Synthetic route
| Conditions | Yield |
|---|---|
| With 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine In dichloromethane at 20℃; for 18h; Acylation; | 96% |
| With dicyclohexyl-carbodiimide |
| Conditions | Yield |
|---|---|
| With 1,4-dioxane at 70 - 80℃; folgendes Destillieren des Reaktionsgemisches; |
| Conditions | Yield |
|---|---|
| With acetic anhydride |
| Conditions | Yield |
|---|---|
| With dichloromethane; mercury(II) oxide |
| Conditions | Yield |
|---|---|
| With diethyl ether |
| Conditions | Yield |
|---|---|
| With oxygen; cobalt(II) acetate; acetic acid at 30℃; unter leichtem Ueberdruck; | |
| With oxygen; copper (I) acetate; acetic acid at 30℃; unter leichtem Ueberdruck; | |
| With oxygen; manganese(II) acetate; acetic acid at 30℃; unter leichtem Ueberdruck; | |
| With oxygen; acetic acid at 30℃; in Gegenwart einer Mischung von Wismut-,Kobalt- und Kupferpulver; |
- 625-35-4, 3488-22-0, 10487-71-5
trans-chrotonyl chloride
- 623-68-7
trans-crotonic anhydride
- 623-68-7
trans-crotonic anhydride
| Conditions | Yield |
|---|---|
| With thionyl chloride; Petroleum ether |
Crotonic Anhydride Chemical Properties
Chemistry informtion about Crotonic Anhydride (CAS NO.623-68-7) is:
IUPAC Name: [(E)-But-2-Enoyl] (E)-But-2-Enoate
Synonyms: 2-Butenoicacid,Anhydride ; Anhydridkyselinykrotonove ; Crotonicacidanhydride ; Crotonic Anhydride ; 2-Butenoic Anhydride ; Trans-2-Butenoic Anhydride ; 2-Butensureanhydrid ; Crotonsaeureanhydrid
Product Categories: Pharmaceutical Intermediates
MF: C8H10O3
MW: 154.16
EINECS: 210-807-1
Density: 1.038 g/cm3
Flash Point: 106.1 °C
Boiling Point: 247 °C at 760 mmHg
Vapour Pressure: 0.0263 mmHg at 25°C
Enthalpy of Vaporization: 48.41 kJ/mol
Refractive Index: n20/D 1.473(lit.)
Following is the molecular structure of Crotonic Anhydride (CAS NO.623-68-7) is:
Crotonic Anhydride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | oral | 2830mg/kg (2830mg/kg) | American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. |
Crotonic Anhydride Consensus Reports
Reported in EPA TSCA Inventory.
Crotonic Anhydride Safety Profile
Moderately toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
C
Risk Statements:
R34:Causes burns.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3265 8/PG 3
WGK Germany: 3
RTECS: GQ6125000
HazardClass: 8
PackingGroup III
Crotonic Anhydride Specification
To protect yourself, you can put on faceshields, full-face respirator (US), gloves, goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter.
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