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EINECS 201-891-0
CAS No. 89-25-8 Density 1.17 g/cm3
Solubility 3 g/L (20 °C) in water Melting Point 126-128 °C(lit.)
Formula C10H10N2O Boiling Point 333 °C at 760 mmHg
Molecular Weight 174.20 Flash Point 155.2 °C
Transport Information Appearance Off white to light yellow powder
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 89-25-8 (3-Methyl-1-phenyl-2-pyrazolin-5-one) Hazard Symbols IrritantXi

C.I. Developer 1;Radicut;CI Developer 1;1-Phenyl-3-methylpyrazolone-5;Methylphenylpyrazolone;3H-Pyrazol-3-one, 2, 4-dihydro-5-methyl-2-phenyl-;2-Pyrazolin-5-one, 3-methyl-1-phenyl-;Edaravone (JAN);3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-;Norphenazone;1-Phenyl-3-methylpyrazolone;1-Phenyl-3-methyl-5-pyrazolone;Developer Z;1-Phenyl-3-methyl-5-oxo-2-pyrazoline;Jarocol PMP;1-Phenyl-3-Methyl-5-Pyrazolone(PMP);1Phenyl 3Methyl 5Pyrazolone;3-methyl-1-phenyl-1H-pyrazol-5(4H)-one;


Edaravone Chemical Properties

Product Name: Norphenazone (CAS NO.89-25-8)
IUPAC Name: 5-methyl-2-phenyl-4H-pyrazol-3-one

Molecular formula: C10H10N2O
Molar mass: 174.2
EINECS: 201-891-0
Melting point: 126-128°C
Boiling point: 287°C 265 mm Hg
Density: 1.12 g/cm3
Flash point: 191°C 17mm
Water Solubility: 3 g/L (20°C)
Stability: stable under ordinary conditions. Light sensitive
Product Categories: Intermediates of Dyes and Pigments; API; Aromatics Compounds; Aromatices; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; ChromophoresPeptide Synthesis; Glycan Labeling; Glycan Labeling and Analysis; OthersDerivatization Reagents; Coupling;Derivatization Reagents HPLC; OthersSynthetic Reagents; Peptide Synthesis; UV-VIS

Edaravone Uses

 Norphenazone (CAS NO.89-25-8) possibly can be used in the synthesis of dyes, drugs,  pesticides and other organic compounds.

Edaravone Toxicity Data With Reference


eye-rbt 500 mg/24H MOD

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,144.

orl-rat LD50:3500 mg/kg

    LONZA#    Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland, to NIOSH, Cincinnati, OH 45226 08FEB79 .

ipr-mus LD50:2012 mg/kg

    RPTOAN    Russian Pharmacology and Toxicology. Translation of FATOAO. 36 (1973),27.


Edaravone Consensus Reports

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-141 ,1978. . Reported in EPA TSCA Inventory.

Edaravone Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Norphenazone (CAS NO.89-25-8):
Hazard Codes: Xi
Risk Statements: 36/37/38:  Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing 
WGK Germany: 1

Edaravone Specification

 Norphenazone, its CAS NO. is 89-25-8, the synonyms are 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one ; 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one .

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