Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Edaravone	EINECS	201-891-0
CAS No.	89-25-8	Density	1.17 g/cm³
PSA	32.67000	LogP	1.29980
Solubility	3 g/L (20 °C) in water	Melting Point	126-128 °C(lit.)
Formula	C₁₀H₁₀N₂O	Boiling Point	333 °C at 760 mmHg
Molecular Weight	174.202	Flash Point	155.2 °C
Transport Information	N/A	Appearance	Off white to light yellow powder
Safety	26-36	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	C.I. Developer 1;Radicut;CI Developer 1;1-Phenyl-3-methylpyrazolone-5;Methylphenylpyrazolone;3H-Pyrazol-3-one, 2, 4-dihydro-5-methyl-2-phenyl-;2-Pyrazolin-5-one, 3-methyl-1-phenyl-;Edaravone (JAN);3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-;Norphenazone;1-Phenyl-3-methylpyrazolone;1-Phenyl-3-methyl-5-pyrazolone;Developer Z;1-Phenyl-3-methyl-5-oxo-2-pyrazoline;Jarocol PMP;1-Phenyl-3-Methyl-5-Pyrazolone(PMP);1Phenyl 3Methyl 5Pyrazolone;3-methyl-1-phenyl-1H-pyrazol-5(4H)-one;	Article Data	198

Edaravone Synthetic route

: 141-97-9
ethyl acetoacetate

: 100-63-0
phenylhydrazine

: 89-25-8
edaravone

Conditions

Conditions	Yield
In acetic acid Heating;	100%
for 0.166667h; Irradiation;	100%
at 0 - 90℃; for 1.5h;	100%

: 105-45-3
acetoacetic acid methyl ester

: 100-63-0
phenylhydrazine

: 89-25-8
edaravone

Conditions

Conditions	Yield
With acetic acid for 3h; Reflux;	98%
With cellulose sulfuric acid In water at 20℃; for 0.133333h; Knorr Pyrazole Synthesis; Green chemistry; regioselective reaction;	92%
With Fe3O4(at)SiO2-bonded N-propyl-diethylenetetrasulfamic acid In water at 20℃; for 0.416667h; Catalytic behavior; Green chemistry;	82%

: 674-82-8
4-methyleneoxetan-2-one

: 100-63-0
phenylhydrazine

: 89-25-8
edaravone

Conditions

Conditions	Yield
Stage #1: 4-methyleneoxetan-2-one With ammonium hydroxide at 10℃; for 0.5h; Stage #2: phenylhydrazine at 60℃; for 2h; Stage #3: With hydrogenchloride In water for 1h; pH=5;	93%

: 13292-56-3
5-methyl-2-phenylpyrazolidin-3-one

: 89-25-8
edaravone

Conditions

Conditions	Yield
With sodium anthraquinone-2-sulfonate; palladium diacetate; potassium carbonate In chlorobenzene at 110℃; for 6h; Reagent/catalyst;	92%

: 27991-08-8
N-acetoacetylphenylhydroxyloamine

A: 100-65-2
N-Phenylhydroxylamine

B: 89-25-8
edaravone

Conditions

Conditions	Yield
With phenylhydrazine In chloroform for 3h; Ambient temperature;	A 90% B 81%

: 59-88-1
phenylhydrazine hydrochloride

: 141-97-9
ethyl acetoacetate

: 89-25-8
edaravone

Conditions

Conditions	Yield
In ethanol at 75℃; for 7h;	85%
In ethanol at 50 - 70℃; for 5h; Reflux;	85%
With ammonia at 95℃; for 6h; pH=6;	85%

: 59-88-1
phenylhydrazine hydrochloride

: 141-97-9
ethyl acetoacetate

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 89-25-8
edaravone

B: 61466-03-3, 4174-09-8
4,4-methine-bis-(3-methyl-1-phenyl-2-pyrazolin-5-one)

Conditions

Conditions	Yield
With p-toluenesulfonic acid monohydrate at 110℃; for 1h; Kinetics; Reagent/catalyst; Temperature;	A 78% B 12%
With pyridine hydrochloride at 140℃; for 24h; Kinetics; Reagent/catalyst;	A 39% B 47%

: 5-isopropoxy-3-methyl-1-phenyl-1H-pyrazole

: 89-25-8
edaravone

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid at 140℃; for 2h; Inert atmosphere;	76%

: 201230-82-2
carbon monoxide

: 78-95-5
chloroacetone

: 100-63-0
phenylhydrazine

: 89-25-8
edaravone

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; triphenylphosphine In tetrahydrofuran at 110℃; under 20521.4 Torr; for 10h; Temperature; Reagent/catalyst; Solvent; Time; Autoclave; regioselective reaction;	72%

: 141-97-9
ethyl acetoacetate

: 89-25-8
edaravone

Conditions

Conditions	Yield
With phenylhydrazine In ethanol	67%
With phenylhydrazine In 1,4-dioxane; water	11.17 g (64%)

Edaravone Chemical Properties

Product Name: Norphenazone (CAS NO.89-25-8)
IUPAC Name: 5-methyl-2-phenyl-4H-pyrazol-3-one

Molecular formula: C₁₀H₁₀N₂O
Molar mass: 174.2
EINECS: 201-891-0
Melting point: 126-128°C
Boiling point: 287°C 265 mm Hg
Density: 1.12 g/cm³
Flash point: 191°C 17mm
Water Solubility: 3 g/L (20°C)
Stability: stable under ordinary conditions. Light sensitive
Product Categories: Intermediates of Dyes and Pigments; API; Aromatics Compounds; Aromatices; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; ChromophoresPeptide Synthesis; Glycan Labeling; Glycan Labeling and Analysis; OthersDerivatization Reagents; Coupling;Derivatization Reagents HPLC; OthersSynthetic Reagents; Peptide Synthesis; UV-VIS

Edaravone Uses

Norphenazone (CAS NO.89-25-8) possibly can be used in the synthesis of dyes, drugs, pesticides and other organic compounds.

Edaravone Toxicity Data With Reference

1.	eye-rbt 500 mg/24H MOD	28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,144.
2.	orl-rat LD50:3500 mg/kg	LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland, to NIOSH, Cincinnati, OH 45226 08FEB79 .
3.	ipr-mus LD50:2012 mg/kg	RPTOAN Russian Pharmacology and Toxicology. Translation of FATOAO. 36 (1973),27.

Edaravone Consensus Reports

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-141 ,1978. . Reported in EPA TSCA Inventory.

Edaravone Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of Norphenazone (CAS NO.89-25-8):
Hazard Codes: Xi
Risk Statements: 36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 1

Edaravone Specification

Norphenazone, its CAS NO. is 89-25-8, the synonyms are 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one ; 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one .

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 89-25-8