Bioorganic and Medicinal Chemistry Letters p. 2463 - 2466 (1996)
Update date:2022-07-29
Topics:
Jarvest, Richard L.
Parratt, Martin J.
Debouck, Christine M.
Gorniak, Joselina G.
Jennings, L. John
Serafinowska, Halina T.
Strickler, James E.
Benzoxazinones have been discovered which are mechanism based inhibitors of HSV-1 protease with micromolar IC50 values. Formation of a monoadduct consistent with the acyl-enzyme complex was detected by mass spectroscopy. A parallel array synthesis was developed to explore 2-heteroatom substituted SAR.
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