Synthesis p. 493 - 495 (1985)
Update date:2022-07-29
Topics:
Randriamahefa, S.
Deschamps, P.
Gallo, R.
Grangette, H.
Tertiary alkylacetic acids (R3CCH2COOH) are prepared by reaction of 1,1-dichloroethene with a reagent capable of forming readily a tertiary alkyl carbenium ion with sulfuric acid in the absence of boron trifluoride.With tertiary butyl reagents, the yields are good and the method is convenient at laboratory and larger scales.The yields of carboxylic acids fall sharply with increasing steric effects.The esters are obtained directly, by adding alcohols, in a one-pot synthesis; with C1-C3 alcohols the reaction is selective.
View MoreChangzhou Sunlight Pharmaceutical Co., Ltd.
Contact:+86-519-83131668;83139028;83138042;83137041
Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
Jintan Jinnuo Chemical Co., Ltd.
Contact:+86-519-80199901
Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
Contact:+86-13666670345
Address:Agricultural Development Zone, Haining, Jiaxing, Zhejiang
Shandong General Materials Co.,Ltd(Shandong Aoertong Chemical Co., Ltd)
Contact:86-531-88072280
Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Beijing Merson Pharmaceutical Co., Ltd
Contact:0086-10-80484934 0086-10-80484574/
Address:2nd Floor , No. 2 Building , No. 14 Houshayu Duan, Jingmi Road ,Shunyi District , Beijing 101318, P.R.China
Doi:10.1002/hlca.19570400216
(1957)Doi:10.1039/d0md00372g
(2021)Doi:10.1016/j.tetlet.2018.01.022
(2018)Doi:10.1021/ja01469a045
(1961)Doi:10.1016/j.molcata.2006.04.025
(2006)Doi:10.1016/j.tetlet.2008.01.004
(2008)