Synthesis p. 493 - 495 (1985)
Update date:2022-07-29
Topics:
Randriamahefa, S.
Deschamps, P.
Gallo, R.
Grangette, H.
Tertiary alkylacetic acids (R3CCH2COOH) are prepared by reaction of 1,1-dichloroethene with a reagent capable of forming readily a tertiary alkyl carbenium ion with sulfuric acid in the absence of boron trifluoride.With tertiary butyl reagents, the yields are good and the method is convenient at laboratory and larger scales.The yields of carboxylic acids fall sharply with increasing steric effects.The esters are obtained directly, by adding alcohols, in a one-pot synthesis; with C1-C3 alcohols the reaction is selective.
View MoreHangzhou Zyter Biological & Chemical Technology Co., Ltd.
website:http://www.zyterpharm.com
Contact:+86-18858184290
Address:West Wenyi Road, Cangqian, Yuhang
Fusilin chemical science & technology co., ltd.
Contact:532-80698166/86057573, +86-400-669-7885
Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong
NIGNXIA XINDACHANG TECHNOLOGY CO.,LTD
website:https://xdcchemical.com/
Contact:86-311-85758226
Address:North Industry Area, Wuji
Yingkou Sanzheng New Technology Chemical Industry Co., Ltd.
Contact:+86-417-2927806
Address:yingkou
Contact:0086-29-88315623
Address:S711, Innovation Bldg No.25 Gaoxin 1st Rd, Xian P.R of China 710075
Doi:10.1002/hlca.19570400216
(1957)Doi:10.1039/d0md00372g
(2021)Doi:10.1016/j.tetlet.2018.01.022
(2018)Doi:10.1021/ja01469a045
(1961)Doi:10.1016/j.molcata.2006.04.025
(2006)Doi:10.1016/j.tetlet.2008.01.004
(2008)