Chemistry of 1,4-dioxene II. A new method for the two-carbon homologation of aldehydes and ketones to α-hydroxymethyl ketones

DOI: 10.1016/S0040-4039(00)98662-3

Source and publish data:

Tetrahedron Letters p. 3453 - 3456 (1985)

Update date:2022-08-04

Topics:

Authors:

Fetizon, Marcel

Hanna, Issam

Rens, Janine

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Article abstract of DOI:10.1016/S0040-4039(00)98662-3

1,4-Dioxen-2-yl lithium 2 reacts with ketones or aldehydes to give alcohols 3 which lead after an allylic rearrangement under mild conditions, followed by reduction and hydrolysis to α-hydroxymethyl ketones in fair yields.

Full text of DOI:10.1016/S0040-4039(00)98662-3

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