SYNTHESIS OF 4-SUBSTITUTED GLUTARIMIDES BY FREE RADICAL ADDITION OF IODOACETAMIDE TO α,β-UNSATURATED ESTERS

Article abstract of DOI:10.1016/S0040-4039(01)80908-4

Free radical addition of either methyl bromoacetate or iodoacetamide to an α,β-unsaturated ester gave the 4-substituted glutarate or glutarimide respectively, whereas the radical cyclisation of N-bromoacetyl crotonamide gave the 2-substituted succinimide.