Conformationally Defined Adrenergic Agents. 3. Modifications to the Carbocyclic Ring of 5,6-Dihydroxy-1-(2-imidazolinyl)tetralin: Improved Separation of α1 and α2 Adrenergic Activities

DOI: 10.1021/jm00158a016

Source and publish data:

Journal of Medicinal Chemistry p. 1413 - 1417 (1986)

Update date:2022-09-26

Topics:

Authors:

DeBernardis, John F.

Winn, Martin

Arendsen, David L.

Kerkman, Daniel J.

Kyncl, John J.

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Article abstract of DOI:10.1021/jm00158a016

A series of modifications to positions 1,2, and 4 of the tetralin ring of 5,6-dihydroxy-1-(2-imidazolinyl)tetralin (1, A-54741) succeeded in improving the separation of the potent α₁ and α₂ adrenergic agonism observed for the parent

Full text of DOI:10.1021/jm00158a016

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