Conformationally Defined Adrenergic Agents. 3. Modifications to the Carbocyclic Ring of 5,6-Dihydroxy-1-(2-imidazolinyl)tetralin: Improved Separation of α1 and α2 Adrenergic Activities

DOI: 10.1021/jm00158a016

Source and publish data:

Journal of Medicinal Chemistry p. 1413 - 1417 (1986)

Update date:2022-09-26

Topics:

Authors:

DeBernardis, John F.

Winn, Martin

Arendsen, David L.

Kerkman, Daniel J.

Kyncl, John J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00158a016

A series of modifications to positions 1,2, and 4 of the tetralin ring of 5,6-dihydroxy-1-(2-imidazolinyl)tetralin (1, A-54741) succeeded in improving the separation of the potent α₁ and α₂ adrenergic agonism observed for the parent

Full text of DOI:10.1021/jm00158a016

Products guided by the article

Product name:trans-5,6-dihydroxy-1-(2-imidazolinyl)-2-phenyltetralin hydrobromide

Cas No:102535-64-8

R&D Labs maybe for 102535-64-8

Hangzhou Hysen Pharma co.,Ltd.

website:http://www.hysenpharma.cn/

Contact:0086-571-88298791

Address:#701,Gudun Road Hangzhou
Yingkou Sanzheng Organic Chemical Co. Ltd.

Contact:+86-417-3638818

Address:25 Gengxinli Village, Daqing Road, Yingkou, Liaoning, China
Hebei Chuncheng Biological Technology Co., Ltd

Contact:86-311-66561796

Address:No. 14 Weiyi Road Salt Chemical Industrial Park Ningjin County Xingtai City Hebei Province China
Shanghai Yurui Biotechnology(Anyang) Pharmaceutical Co., Ltd

Contact:+86-0372-3662335 +86-0372-3661988

Address:hanling industrial park anyang
Changzhou Anchor Biological Technology Co., Ltd.

website:http://www.ankerbio.com/contact_en.html

Contact:+86-519-85519868/18915088828

Address:No.1307,Building 4,Wujin Wanda Plaza,Hutang Town,Wujin District

Relevant to this article

Catalytic dehydrogenation of cyclooctane in homogeneous solution with titanium, zirconium and hafnium complexes containing N,O-chelating ligands

Doi:10.1016/j.molcata.2008.04.005
(2008)
Intramolecular nucleophilic acyl substitution reaction of 3,4-alkadienyl carbonates mediated by Ti(O-i-Pr)₄/2 i-PrMgCl reagent. Efficient synthesis of optically active β,γ-unsaturated esters with an α-substituent

Doi:10.1021/jo961401t
(1996)
Synthesis and application of melamine-based nano catalyst with phosphonic acid tags in the synthesis of (3′-indolyl)pyrazolo[3,4-b]pyridines via vinylogous anomeric based oxidation

Doi:10.1016/j.mcat.2019.110666
(2020)
Structure-activity relationship of omeprazole and analogues as Helicobacter pylori urease inhibitors

Doi:10.1021/jm00025a008
(1995)
Microwave irradiation assisted synthesis, alkylation reaction, and configuration analysis of aryl pyrogallol[4]arenes

Doi:10.1016/j.tet.2007.07.043
(2007)
Doi:10.1039/jr9570001816
(1957)

Article Doi