Synthesis and Antihypertensive Activity of Pyran Oxygen and Amide Nitrogen Replacement Analogues of the Potassium Channel Activator Cromakalim

DOI: 10.1021/jm00115a015

Source and publish data:

Journal of Medicinal Chemistry p. 3261 - 3267 (1991)

Update date:2022-07-30

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Authors:

Ashwood, Valerie A.

Cassidy, Frederick

Evans, John M.

Gagliardi, Stefania

Stemp, Geoffrey

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Article abstract of DOI:10.1021/jm00115a015

The synthesis and oral antihypertensive activity in conscious spontaneously hypertensive rats of two new series of compounds related to the prototype potassium channel activator cromakalim (1) are described.In the first series, replacement of the benzopyr

Full text of DOI:10.1021/jm00115a015

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