Synthesis and Antihypertensive Activity of Pyran Oxygen and Amide Nitrogen Replacement Analogues of the Potassium Channel Activator Cromakalim

DOI: 10.1021/jm00115a015

Source and publish data:

Journal of Medicinal Chemistry p. 3261 - 3267 (1991)

Update date:2022-07-30

Topics:

Authors:

Ashwood, Valerie A.

Cassidy, Frederick

Evans, John M.

Gagliardi, Stefania

Stemp, Geoffrey

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00115a015

The synthesis and oral antihypertensive activity in conscious spontaneously hypertensive rats of two new series of compounds related to the prototype potassium channel activator cromakalim (1) are described.In the first series, replacement of the benzopyr

Full text of DOI:10.1021/jm00115a015

Products guided by the article

Product name:Propanedioic acid, [2-(4-bromophenyl)-1,1-dimethylethyl]-, diethyl ester

Cas No:102568-18-3

R&D Labs maybe for 102568-18-3

JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD

website:http://www.xypharm.com/

Contact:+86-515-84383317

Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China
Xiamen Kaijia Imp & Exp Co., Ltd.

Contact:86-592-5101177

Address:Room406 Luhui Building No. 65 Haitian Road Huli Xiamen,China.
Chinese Peptide Company

Contact:86-571-86737118-8689

Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Beijing Mashi Fine Chemical Co.,Ltd.

Contact:+86-10-61271592

Address:Room 506, Section B, Kaichi Mansion, Industrial Development
Jinan Yijialian Economic and Trade Development Co., Ltd.

Contact:+86 0531-66729596

Address:jinan

Relevant to this article

The Cathodic Cleavage of the 4-Nitrobenzyloxycarbonyl Group from Amine Derivatives in Aprotic Conditions

Doi:10.1039/P29880000409
(1988)
Synthesis and Pharmacological Evaluation of 2'-Hydroxychalcones and Flavones as Inhibitors of Inflammatory Mediators Generation

Doi:10.1021/jm00014a032
(1995)
Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain

Doi:10.1021/jm990171i
(1999)
A Second-Generation Synthesis of the C1-C28 Portion of the Altohyrtins (Spongistatins)

Doi:10.1021/ja030316h
(2003)
Nano silica sulfuric acid an efficient and recoverable heterogeneous catalyst for the preparation of amidoalkyl naphthols under solvent-free conditions

Doi:10.1080/15533174.2013.809746
(2015)
The aluminum amalgam reduction of 2-nitroalkanols promoted by ultrasound

Doi:10.1016/0040-4039(94)88062-X
(1994)

Article Doi