European Journal of Medicinal Chemistry p. 3 - 10 (1994)
Update date:2022-07-30
Topics:
Chern, JW
Wise, DS
Shewach, DS
Daddona, PE
Townsend, LB
Several 8-amino-9-(benzyl)guanines were selected for synthesis as potential purine nucleoside phosphorylase (PNP) inhibitors on the basis of the Topliss decision tree.These compounds were prepared by the treatment of oxazolo<5,4-d>pyrimidine intermediates
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