Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: Synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles

DOI: 10.1021/jm00047a009

Source and publish data:

Journal of Medicinal Chemistry p. 3511 - 3522 (1994)

Update date:2022-07-31

Topics:

Authors:

Higley Higley

Wilde Wilde

Maduskuie

Johnson Johnson

Pennev Pennev

Billheimer

Robinson

Gillies Gillies

Wexler Wexler

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00047a009

A series of 4,5-diaryl-2-(substituted thio)-1H-imidazoles has been synthesized and demonstrated to be potent inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). The design, synthesis, and structure-activity relationships for this series are reporte

Full text of DOI:10.1021/jm00047a009

Products guided by the article

Product name:2-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-N-heptyl-acetamide

Cas No:1025988-04-8

R&D Labs maybe for 1025988-04-8

Chengdu King-tiger Pharm-chem. Tech. Co., Ltd

Contact:028-85317716

Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.
Shanghai Micro-mega Industry Co., Ltd.

Contact:0086-21-34628682;57153848

Address:Rm413,No.413,West Meilong Road, Minhang District,Shanghai P R China
Joyochem Co., Ltd.

website:https://sdjingyuan.lookchem.com/

Contact:86-531-82687998

Address:Factory Building 11, Jinan Comprehensive free trade zone, Shandong, China
Shanghai Bojing Chemical Co., Ltd.

Contact:021-37122233

Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
Hangzhou LINGEBA Technology Co., Ltd.

Contact:+0086-571-87389059

Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China

Relevant to this article

New boronic-acid- and boronate-substitued aromatic compounds as precursors of fluoride-responsive conjugated polymer films

Doi:10.1002/(SICI)1099-0690(200005)2000:9<1703::AID-EJOC1703>3.0.CO;2-S
(2000)
N-phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: Structure-activity studies and demonstration of in vivo activity

Doi:10.1021/jm980072p
(1998)
Synthesis and Antiulcer Activity of 5,11-Dihydro<1>benzoxepino<3,4-b>pyridines

Doi:10.1021/jm00399a016
(1988)
Construction of an asymmetric quaternary carbon via an asymmetric aza-Claisen rearrangement and its application in the total synthesis of (+)-α-cuparenone

Doi:10.1016/j.tetasy.2012.05.016
(2012)
Gold(I)-catalyzed regio- and stereoselective 1,3-dipolar cycloaddition reactions of 1-(1-Alkynyl)cyclopropyl oximes with nitrones: A modular entry to highly substituted pyrrolo[3,4-d][1,2]oxazepines

Doi:10.1002/adsc.201200288
(2012)
A NEW ENTRY TO HOMOCHIRAL DIFLUORINATED COMPOUNDS

Doi:10.1016/S0957-4166(00)82007-8
(1991)

Article Doi