Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: Synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles

DOI: 10.1021/jm00047a009

Source and publish data:

Journal of Medicinal Chemistry p. 3511 - 3522 (1994)

Update date:2022-07-31

Topics:

Authors:

Higley Higley

Wilde Wilde

Maduskuie

Johnson Johnson

Pennev Pennev

Billheimer

Robinson

Gillies Gillies

Wexler Wexler

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Article abstract of DOI:10.1021/jm00047a009

A series of 4,5-diaryl-2-(substituted thio)-1H-imidazoles has been synthesized and demonstrated to be potent inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). The design, synthesis, and structure-activity relationships for this series are reporte

Full text of DOI:10.1021/jm00047a009

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