Concise syntheses of the oxo derivatives of benzo[c]phenanthridine bases by N-deformylated cyclization based on Vilsmeier-Haack reaction

DOI: 10.1248/cpb.43.766

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 766 - 770 (1995)

Update date:2022-09-26

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Authors:

Ishikawa

Takami Takami

Abe Abe

Chen Chen

Harayama

Ishii Ishii

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Article abstract of DOI:10.1248/cpb.43.766

Chelerythrine-type oxobenzo[c]phenanthridine bases were effectively synthesized by the action of 1,3-dimethoxybenzene on 2-(2-methoxycarbonylphenyl)-1-(N-methylformamido)naphthalenes in the presence of phosphorus oxychloride. The N-deformylation based on the Vilsmeier-Haack reaction is also discussed.

Full text of DOI:10.1248/cpb.43.766

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