Synthesis of the C16-C23 effector domain of FK-506 via copper-catalysed metallate rearrangement of an α-alkoxyalkenylcuprate

DOI: 10.1055/s-1995-3871

Source and publish data:

Synthesis p. 195 - 198 (1995)

Update date:2022-08-02

Topics:

Authors:

Jarowicki

Kocienski

Norris Norris

O'Shea O'Shea

Stocks Stocks

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Article abstract of DOI:10.1055/s-1995-3871

A 1,2-metallate rearrangement of the putative higher order cuprate 17 derived from reaction of the metallated dihydrofuran 15 with the homocuprate 16 occurred with clean inversion of configuration to give the alkenylcuprate 18. Methylation of 18 followed

Full text of DOI:10.1055/s-1995-3871

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