Synthesis and analysis of compounds having the skeleton of ergot alkaloids with the nitrogen atom in the D-ring transposed

Article abstract of DOI:10.1002/jhet.5570320435

Alkylation-amination of the enamine 2 in the presence of ethyl α,α-bis(dibromomethyl)acetate, triethylamine, and methylamine lead to the construction of the aza-transposed ergoline 3. Sequential reduction, hydrolysis, reesterification, and indolization of