Monophthalates with oxidized C5-carbon in the ester chain: A simple synthetic access to two major metabolites of bis-(2-ethylhexyl)-phthalate

Article abstract of DOI:10.1007/s007060200084

The synthesis of two oxidized metabolites of bis-(2-ethylhexyl)-phthalate is described. The target structures were obtained by esterification of the appropriate alcohol carrying a protected hydroxy group with phthalic anhydride, followed by deprotection and further oxidation.