Syntheses and biological activities of new N1-aryl substituted quinolone antibacterials

DOI: 10.1002/ardp.19963290403

Source and publish data:

Archiv der Pharmazie p. 179 - 190 (1996)

Update date:2022-08-04

Topics: Biological activities Syntheses Quinolone Antibacterials

Authors:

Juergens, Jens

Schedletzky, Holger

Heisig, Peter

Seydel, Joachim K.

Wiedemann, Bernd

Holzgrabe, Ulrike

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Article abstract of DOI:10.1002/ardp.19963290403

A series of quinolones with a systematically varied substitution at the phenyl ring at N1 has been synthesized. Three lipophilicity descriptors (log K, log P, R(m)) and the pK(a) values have been determined as well as the microbiological activity: The MIC

Full text of DOI:10.1002/ardp.19963290403

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