Archiv der Pharmazie p. 179 - 190 (1996)
Update date:2022-08-04
Topics: Biological activities Syntheses Quinolone Antibacterials
Juergens, Jens
Schedletzky, Holger
Heisig, Peter
Seydel, Joachim K.
Wiedemann, Bernd
Holzgrabe, Ulrike
A series of quinolones with a systematically varied substitution at the phenyl ring at N1 has been synthesized. Three lipophilicity descriptors (log K, log P, R(m)) and the pK(a) values have been determined as well as the microbiological activity: The MIC
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