Syntheses and β-adrenergic agonist and antiaggregatory properties of N-substituted trimetoquinol analogues

Article abstract of DOI:10.1021/jm00159a008

Trimetoquinol [1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, TMQ] is a potent β-adrenergic receptor agonist and inhibitor of human platelet aggregation. Selective cleavage of O-benzyl groups in the presence of an N-benzyl group