Journal of Medicinal Chemistry p. 1760 - 1764 (1986)
Update date:2022-08-04
Topics:
Iyengar, Bhashyam S.
Sami, Salah M.
Takahashi, Takeo
Sikorski, Elizabeth E.
Remers, Wiliam A.
Bradner, Wiliam T.
Twenty-three mitomycin C analogues designed to have increased metal complexing ability were synthesized and tested against P388 leukemia in mice.Their ability to complex Cu(II) was revealed by the shifts in their UV absorption spectra caused by this metal.One analogue was clearly more active than mitomycin C in the antitumor assay and two others had good activity.Correlation between antitumor activity and Cu(II) complexing ability was ambiguous.The most active compounds were either not complexers or they were complexers limited to the 2-(2-pyridyl)alkyl type substituent on N7.A variety of amino acid substituents on N7 showed only weak antitumor activity.
View MoreWuxi Forest Biological Co.,Ltd
Contact:+86-510-81602300
Address:Room 317,Building D, No.159 middle Chengjiang Road,Jiangyin Wuxi city.
Chongqing Rong＆Quan Pharmaceutical Technology Co. , Ltd.
Contact:86-023-65268721
Address:No. 7, Manshanhong Village, Pingdingshan, Shapingba District, Chongqing Province, China
website:http://www.afinechem.com
Contact:+86-571-85134551
Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
ZhangJiaGang YaRui Chemical Co.,Ltd.
Contact:0512-58360968
Address:China JiangSu Province Zhang Jia Gang City YangShe Oriental Plaza Building 10 B307
Neworld Chemical Co., Ltd Shanghai(expird)
Contact:+86-21-62202658
Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Doi:10.1021/jo800473x
(2008)Doi:10.1002/ejoc.200701140
(2008)Doi:10.1007/BF00938577
(1952)Doi:10.1081/NCN-200040614
(2004)Doi:10.1021/jo00360a010
(1986)Doi:10.1007/s10870-013-0401-6
(2013)
