Journal of Medicinal Chemistry p. 1760 - 1764 (1986)
Update date:2022-08-04
Topics:
Iyengar, Bhashyam S.
Sami, Salah M.
Takahashi, Takeo
Sikorski, Elizabeth E.
Remers, Wiliam A.
Bradner, Wiliam T.
Twenty-three mitomycin C analogues designed to have increased metal complexing ability were synthesized and tested against P388 leukemia in mice.Their ability to complex Cu(II) was revealed by the shifts in their UV absorption spectra caused by this metal.One analogue was clearly more active than mitomycin C in the antitumor assay and two others had good activity.Correlation between antitumor activity and Cu(II) complexing ability was ambiguous.The most active compounds were either not complexers or they were complexers limited to the 2-(2-pyridyl)alkyl type substituent on N7.A variety of amino acid substituents on N7 showed only weak antitumor activity.
View MoreBeijing Stable Chemcial Co.ltd
Contact:86-10-63785052
Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China
ABA Chemicals (Shanghai) Limited
Contact:021- 5115 9199-232
Address:Suite 18D, #201 Ningxia Road,
Chongqing Yawei Fine Chemical Co.,Ltd
Contact:0086-23-62849407
Address:Ziyou village, Nanquan town, Banan district, Chongqing China
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd
Contact:0086-10-64430626
Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
website:http://www.easchem.com
Contact:+86-731-89722861 89722891
Address:2/F-4/Bld Colorful Palace, No.605 Changsha Ave, Yuhua Area Changsha Hunan China.
Doi:10.1021/jo800473x
(2008)Doi:10.1002/ejoc.200701140
(2008)Doi:10.1007/BF00938577
(1952)Doi:10.1081/NCN-200040614
(2004)Doi:10.1021/jo00360a010
(1986)Doi:10.1007/s10870-013-0401-6
(2013)
