Differential effects of stereochemistry and C-4 substituents on the enantioselectivity of PLE and PPL catalysed hydrolysis of 3,4-disubstituted β-lactams

DOI: 10.1016/S0040-4039(96)02381-7

Source and publish data:

Tetrahedron Letters p. 643 - 646 (1997)

Update date:2022-07-30

Topics:

Authors:

Basak, Amit

Mahato, Tapan

Bhattacharya, Gautam

Mukherjee, Ballari

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Article abstract of DOI:10.1016/S0040-4039(96)02381-7

Pig Liver Esterase (PLE) and Pig Pancreas Lipase (PPL)catalysed hydrolysis of (±) trans-3-carbethoxy and (±)cis-3-acetoxymethyl 4-substituted β-lactams revealed interesting dependence on C-3, C-4 stereochemistry and nature of C-4 substituents.

Full text of DOI:10.1016/S0040-4039(96)02381-7

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