Versatile synthesis of quinoline-3-carboxylic esters and indol-2-acetic esters by palladium-catalyzed carbonylation of 1-(2-aminoaryl)-2-Yn-1-Ols

DOI: 10.1021/jo8006495

Source and publish data:

Journal of Organic Chemistry p. 4971 - 4977 (2008)

Update date:2022-08-04

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Authors:

Gabriele, Bartolo

Mancuso, Raffaella

Salerno, Giuseppe

Lupinacci, Elvira

Ruffolo, Giuseppe

Costa, Mirco

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Article abstract of DOI:10.1021/jo8006495

(Chemical Equation Presented) 1-(2-Aminoaryl)-2-yn-1-ols, easily obtained by the Grignard reaction between 1-(2-aminoaryl)ketones and alkynylmagnesium bromides, were subjected to carbonylative conditions in the presence of the PdI₂-KI catalytic

Full text of DOI:10.1021/jo8006495

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Product name:6-chloro-4-methyl-2-phenylquinoline-3-carboxylic acid methyl ester

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