Bioorganic and Medicinal Chemistry p. 6009 - 6020 (2008)
Update date:2022-08-04
Topics:
Severino, Beatrice
Fiorino, Ferdinando
Perissutti, Elisa
Frecentese, Francesco
Cirino, Giuseppe
Roviezzo, Fiorentina
Santagada, Vincenzo
Caliendo, Giuseppe
Protease-activated receptor-1 (PAR-1) is a G-coupled receptor activated by α-thrombin and other proteases. In this paper we describe the synthesis and the pharmacological evaluation of novel peptide-mimetic antagonists (compounds 1-16) characterized by th
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