Synthesis of 2′-N-methylamino-2′-deoxyguanosine and 2′- N, N-dimethylamino-2′-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry

Article abstract of DOI:10.1021/jo201364x

The 2′-hydroxyl groups within RNA contribute in essential ways to RNA structure and function. Previously, we designed an atomic mutation cycle (AMC) that uses ribonucleoside analogues bearing different C-2′-substituents, including -OCH₃, -NH