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Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 inhibitors. Part II: Replacing the heterocycle

DOI: 10.1016/0960-894X(95)00564-A

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 87 - 92 (1996)

Update date:2022-08-02

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Authors:

Gauthier, Jacques YvesGauthier, Jacques Yves

Leblanc, YvesLeblanc, Yves

Black, W. CameronBlack, W. Cameron

Chan, Chi-ChungChan, Chi-Chung

Cromlish, Wanda A.Cromlish, Wanda A.

Gordon, RobertGordon, Robert

Kennedey, Brian P.Kennedey, Brian P.

Lau, Cheuk K.Lau, Cheuk K.

Leger, SergeLeger, Serge

Wang, ZhaoyinWang, Zhaoyin

Ethier, DianeEthier, Diane

Guay, JocelyneGuay, Jocelyne

Mancini, JosephMancini, Joseph

Riendeau, DenisRiendeau, Denis

Tagari, PhilipTagari, Philip

Vickers, PhilipVickers, Philip

Wong, ElizabethWong, Elizabeth

Xu, LijingXu, Lijing

Prasit, PeptiboonPrasit, Peptiboon

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Article abstract of DOI:10.1016/0960-894X(95)00564-A

The thiophene ring of DuP 697 was replaced by a variety of heterocycles and the products were tested for their ability to inhibit human Cox-2 and Cox-1, the isozymes of cyclooxygenase.

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Full text of DOI:10.1016/0960-894X(95)00564-A

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