Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 inhibitors. Part II: Replacing the heterocycle

Article abstract of DOI:10.1016/0960-894X(95)00564-A

The thiophene ring of DuP 697 was replaced by a variety of heterocycles and the products were tested for their ability to inhibit human Cox-2 and Cox-1, the isozymes of cyclooxygenase.