CONDENSED CYCLIC AND BRIDGED-RING SYSTEMS : PART 12. A NOVEL SYNTHETIC ROUTE TO 4-p-METHOXYPHENYL-BICYCLOOCTAN-2-ONES AND SOME BICYCLOOCTANE DERIVATIVES BY ACID-CATALYZED INTRAMOLECULAR C-ALKYLATION AND REARRANGEMENT REACTIONS.

Article abstract of DOI:10.1016/S0040-4020(01)91364-X

The efficacy of a new acid-catalyzed intramolecular C-alkylation has been demonstrated by the synthesis of 1-methyl-4-p-methoxyphenylbicyclo<2.2.2>octan-2-one (5) and 4-p-methoxy-phenylbicyclo<2.2.2>octan-2-one (6) from easily accessible starting material