TOTAL SYNTHESIS OF THE IONOPHORE ANTIBIOTIC IONOMYCIN. ASYMMETRIC SYNTHESIS OF THE C1-C10 AND C11-C16 SYNTHONS.

Article abstract of DOI:10.1016/S0040-4039(86)80034-X

Asymmetric synthesis of the synthons 1 and 3 are described.Absolute stereochemical relationships in these intermediates have been established via chiral enolate and directed hydrogenation processes.