Pyloricidins, novel anti-Helicobacter pylori antibiotics produced by Bacillus sp. II. Isolation and structure elucidation

Article abstract of DOI:10.7164/antibiotics.54.934

Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A₁, A₂, B, C and D were isolated from Bacillus sp. HC-70 and Bacillus sp. HC-72 by column chromatographies using adsorption and ion exchange resins. Their structures have been elucidated based on spectroscopic and degradation studies and shown to be peptide-like compounds. These compounds contained two unusual amino acids, viz., 5-amino-2,3,4,6-tetrahydroxyhexanoic acid and 3-amino-3-phenylpropionic acid (β-phenylalanine). The structure-activity relationship studies suggested that 3-(5-amino-2,3,4,6-tetrahydroxyhexanoyl)amino-3-phenylpropionic acid moiety was essential for anti-H. pylori activity.