An efficient method for the synthesis of 4,5-disubstituted catechols

Article abstract of DOI:10.1246/bcsj.73.747

4,5-Disubstituted catechols were prepared in high yields via successive Friedel-Crafts acylation in the presence of a Ti(IV) catalyst or I₂ and reduction with triethylsilane of veratroles. This method provides an effective and well-regulated synthetic strategy toward catechol derivatives having a variety of substituents at the 4- and 5- positions.