Synthesis and activity of novel nitropyrazines for use as hypoxic cell radiosensitizers

DOI: 10.1021/jm00378a018

Source and publish data:

Journal of Medicinal Chemistry p. 1634 - 1639 (1984)

Update date:2022-08-05

Topics:

Authors:

Hartman Hartman

Schwering

Saari Saari

Engelhardt

Jones Jones

Wardman Wardman

Watts Watts

Woodcock

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Article abstract of DOI:10.1021/jm00378a018

A series of eight novel nitropyrazines has been prepared by oxidation of sulfoximine intermediates. The partition coefficient, one-electron reduction potential, sensitizer enhancement ratio, and chronic and acute aerobic cytotoxicity have been measured for each. Two representatives of this series were tested in the Ames test and were not found to be mutagenic.

Full text of DOI:10.1021/jm00378a018

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