Synthesis and activity of novel nitropyrazines for use as hypoxic cell radiosensitizers

DOI: 10.1021/jm00378a018

Source and publish data:

Journal of Medicinal Chemistry p. 1634 - 1639 (1984)

Update date:2022-08-05

Topics:

Authors:

Hartman Hartman

Schwering

Saari Saari

Engelhardt

Jones Jones

Wardman Wardman

Watts Watts

Woodcock

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00378a018

A series of eight novel nitropyrazines has been prepared by oxidation of sulfoximine intermediates. The partition coefficient, one-electron reduction potential, sensitizer enhancement ratio, and chronic and acute aerobic cytotoxicity have been measured for each. Two representatives of this series were tested in the Ames test and were not found to be mutagenic.

Full text of DOI:10.1021/jm00378a018

Products guided by the article

Product name:2-Chloro-3-nitroso-pyrazine

Cas No:105410-36-4

R&D Labs maybe for 105410-36-4

Hangzhou GreenCo Science & Technology Co., Ltd.

Contact:86-571-88257303

Address:1713 Room,Jingui Building,Gudun Road,Xihu District,Hangzhou,China
SHIJIAZHUANG HENRYTE CHEMICALS CO,.LTD(expird)

Contact:+86-311-85208698 311-80837698

Address:NO.166, yuhua west road, SHIJIAZHUANG, China
enantiotech corporation ltd

Contact:+86-0760-85282375

Address:zhongjing road,zhongshan torch hi-tech industrial development zone
Angelisun(Chongqing) Pharmaceutical Co., LTD.

Contact:+86-23-68030926-816

Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
Synochem Ingredients Corp., Ltd.

Contact:+86-512-5636 2180

Address:Zhangjiagang Free Trade Zone

Relevant to this article

Controlled assembly of zero-, one- and two-dimensional metal-organic frameworks involving in situ ligand synthesis under different reaction pH

Doi:10.1016/j.poly.2008.04.035
(2008)
A NOVEL NUCLEOPHILIC SUBSTITUTION OF THE FORMYL GROUP IN p-NITROBENZALDEHYDE WITH SOME CARBANIONS

Doi:10.1246/cl.1986.173
(1986)
Oxidation of Silyl Enol Ethers Using 2-Sulfonyloxaziridines. Synthesis of α-Siloxy Epoxides and α-Hydroxy Carbonyl Compounds

Doi:10.1021/jo00381a051
(1987)
A synthesis of methyl 3-O-α-D-mannopyranosyl-α-D-mannopyranoside and related disaccharides

Doi:10.1016/S0008-6215(00)90315-X
(1986)
Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for ras guanyl nucleotide-releasing proteins

Doi:10.1021/jm800380b
(2008)
Isosteric exchange of the acylsulfonamide moiety in Abbott's Bcl-X_L protein interaction antagonist

Doi:10.1016/j.bmcl.2008.05.096
(2008)

Article Doi