Trifluoropyruvic Acid Hydrate in Heterocyclic Synthesis: a Facile Synthesis of 5-Hydroxy-5-Trifluoromethylhydantoin Derivatives

Article abstract of DOI:10.1016/S0022-1139(00)85100-3

The reaction of trifluoropyruvic acid hydrate with urea derivatives affords 5-hydroxy-5-trifluoromethylhydantoin derivatives in good yields.The product orientation is consistent with the initial attack on the most active center, in trifluoropyruvic acid h