Novel Inhibitors of Prolyl 4-Hydroxylase. 5. The Intriguing Structure-Activity Relationships Seen with 2,2'-Bipyridine and its 5,5'-Dicarboxylic Acid Derivatives

DOI: 10.1021/jm00076a014

Source and publish data:

Journal of Medicinal Chemistry p. 3853 - 3858 (1993)

Update date:2022-08-04

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Authors:

Hales, Neil J.

Beattie, John F.

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Article abstract of DOI:10.1021/jm00076a014

Members of a series of 2,2'-bipyridines have been synthesized and tested as inhibitors of prolyl hydroxylase (EC 1.14.11.2).The structure-activity relationships seen with <2,2'-bipyridine>-5-carboxylic acid (4) closely resemble those of pyridine-2-carboxy

Full text of DOI:10.1021/jm00076a014

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