Novel Inhibitors of Prolyl 4-Hydroxylase. 5. The Intriguing Structure-Activity Relationships Seen with 2,2'-Bipyridine and its 5,5'-Dicarboxylic Acid Derivatives

DOI: 10.1021/jm00076a014

Source and publish data:

Journal of Medicinal Chemistry p. 3853 - 3858 (1993)

Update date:2022-08-04

Topics:

Authors:

Hales, Neil J.

Beattie, John F.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00076a014

Members of a series of 2,2'-bipyridines have been synthesized and tested as inhibitors of prolyl hydroxylase (EC 1.14.11.2).The structure-activity relationships seen with <2,2'-bipyridine>-5-carboxylic acid (4) closely resemble those of pyridine-2-carboxy

Full text of DOI:10.1021/jm00076a014

Products guided by the article

Product name:5'-(ethoxycarbonyl)-2,2'-bipyridine-5-carboxylic acid

Cas No:105501-69-7

R&D Labs maybe for 105501-69-7

Beijing Tianjia Chemical Science & Technology Co.,Ltd

Contact:86-0550-2392698

Address:No.388, Shiliang Road (East),
Hunan Zhongqi Pharmaceutical Co., Ltd

website:http://www.hnzqzy.com

Contact:0730-8722288 13807308622

Address:Wanjiafan Road ,Yueyang Economic And Technological Development Zone ,Hunan,PRC
Rizhao Lanxing Chemical Indusrial Co.,Ltd

Contact:86-633-2616708

Address:NO.15 West road Shenglan, Lanshan district, Rizhao City
Jiangsu Chiatai Qingjiang Pharmaceutical Co.,Ltd

Contact:+86-517-86283327

Address:9 North Hantai Road, Huaian, China
Beijing Stable Chemcial Co.ltd

Contact:86-10-63785052

Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China

Relevant to this article

Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents

Doi:10.3390/molecules190915237
(2014)
Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR)

Doi:10.1016/j.bmcl.2008.06.018
(2008)
Convenient preparation of N-monosubstituted S,S-diarylsulfodiimides using fluoro-λ⁶-sulfanenitriles

Doi:10.1055/s-2008-1067090
(2008)
Mechanistic Insight into Catalytic Redox-Neutral C-H Bond Activation Involving Manganese(I) Carbonyls: Catalyst Activation, Turnover, and Deactivation Pathways Reveal an Intricate Network of Steps

Doi:10.1021/jacs.8b09095
(2019)
SYNTHESIS OF C-METHYLDESOXY SUGARS: DESOXYGENATION OF TERTIARY ALCOHOL XANTHOGENATES AND HYDROZIRCONATION OF EXOMETHYLENE DERIVATIVES OF CARBOHYDRATES

Doi:10.1007/BF00952937
(1986)
Palladium-catalyzed direct Hiyama arylation of quinoxalin-2(1H)-ones with aryl siloxanes in water

Doi:10.1016/j.tetlet.2020.152612
(2020)

Article Doi