Novel Inhibitors of Prolyl 4-Hydroxylase. 5. The Intriguing Structure-Activity Relationships Seen with 2,2'-Bipyridine and its 5,5'-Dicarboxylic Acid Derivatives

Article abstract of DOI:10.1021/jm00076a014

Members of a series of 2,2'-bipyridines have been synthesized and tested as inhibitors of prolyl hydroxylase (EC 1.14.11.2).The structure-activity relationships seen with <2,2'-bipyridine>-5-carboxylic acid (4) closely resemble those of pyridine-2-carboxy