An efficient synthesis of (+)-epi-cytoxazone via asymmetric organocatalysis

Article abstract of DOI:10.1016/j.tetasy.2008.06.021

The catalytic enantioselective synthesis of (+)-epi-cytoxazone has been accomplished in four steps from p-methoxybenzaldehyde N-Boc-imine with good diastereo- and enantioselectivity. This approach involves asymmetric Mannich reaction of an aldehyde with N