Tetrahedron p. 2717 - 2726 (1985)
Update date:2022-08-05
Topics:
Cristau
Plenat
Duc
Bennamara
A new way to 1,4 butadienylene bisphosphonium salts 2 is given, using a base-catalyzed double isomerization process on acetylenic precursors 3. The precursor can be synthetized by nucleophilic substitution of 1,4-diiodo 2-butyne with triphenylphosphine. The selection of the 1,4-dihalo 2-butyne has a strong influence on the course of the reaction which, besides that, can lead to exclusive formation of a new stabilized ylid-disalt 5. The stereoselectivity of the t.butylamine induced double isomerization allows the isolation of the kinetic product, the (Z, E) 1,4-butadienylene bisphosphoniun salt, which is then readily converted into the more stable (E, E) isomer.
Zibo Xiaoguang Chemical Material Co., Ltd
Contact:15954099116
Address:Boshan Development Zone
Contact:86-511-85210668 0511-85210668, 85210818, 85210898
Address:Yihai Garden E-902,NO.99 Daxi RD., Zhenjiang Jiiangsu ,China
Contact:+33-5-34012600
Address:28 ZA des Pignès
Zhejiang kehong chemical co., ltd
Contact:0086-575-85522000
Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Shanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Doi:10.1007/s11172-007-0189-7
(2007)Doi:10.1021/jo00381a009
(1987)Doi:10.1002/hlca.201000361
(2011)Doi:10.1039/c0ob00205d
(2010)Doi:10.1002/hlca.19640470209
(1964)Doi:10.1021/jm00095a023
(1992)
