Synthesis of 2-Hydroxy-3-(ethoxycarbonyl)-1,2,3,4-tetrahydro-β-carbolines from N-Hydroxytryptophans. An Approach to the Eudistomin Series

DOI: 10.1021/jo00380a014

Source and publish data:

Journal of Organic Chemistry p. 555 - 560 (1987)

Update date:2022-07-29

Topics:

Authors:

Plate, Ralf

Hout, Ruud H. M. van

Behm, Helmut

Ottenheijm, Harry C. J.

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Article abstract of DOI:10.1021/jo00380a014

Pictet-Spengler condensations of the N-hydroxytryptophan ethyl esters 5a and 5b with acetals 6a-c and aldehydes 9a,b have been evaluated.These reactions provide an access to the 2-hydroxy-β-carbolines 7a-d, 8a-d, and 10a,b-12a,b.Removal of the sulfur prot

Full text of DOI:10.1021/jo00380a014

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