Folate Analogues as Inhibitors of Thymidylate Synthase

DOI: 10.1021/jm00387a016

Source and publish data:

Journal of Medicinal Chemistry p. 675 - 678 (1987)

Update date:2022-07-29

Topics:

Authors:

Brixner, Diana I.

Ueda, Takamori

Cheng, Yung-Chi

Hynes, John B.

Broom, Arthur D.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00387a016

Recent demonstrations that deazafolate analogues may act as potent inhibitors of thymidylate synthase (TS) provided a firm rationale for the synthesis of N¹⁰-propargyl derivatives of 8-deazafolate (3) and 8-deazaaminopterin (4).A complete assig

Full text of DOI:10.1021/jm00387a016

Products guided by the article

Product name:diethyl N-<4-<<(2,4-diaminopyrido<3,2-d>pyrimidin-6-yl)methyl>propargylamino>benzoyl>-L-glutamate

Cas No:106500-90-7

R&D Labs maybe for 106500-90-7

JIANGXI AIFEIMU TECHNOLOGY CO.，LTD

Contact:+86-570-6040289

Address:FINECHEMICAL PARK,ZIBU TOWN,WANNIAN COUNTY,JIANGXI PROV.,CHINA,ZIP
Weifang Adde Economic And Trade Co.,LTD.

Contact:86-536-8885548

Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
Hunan Russell Chemicals Technology Co.,Ltd

website:http://www.russellchem.com

Contact:0086-182-2994-0868

Address:Buiding4,Lugu Enterprise Plaza, Yuelu Distric
Zibo Ocean International Trade Co.,Ltd(expird)

Contact:+86 533 5160706

Address:1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China
Jining Shengrun Chemical Industry Co., Ltd.

Contact:+86-537-7121666 ,

Address:West Ring Road,Wenshang County Shandong Province

Relevant to this article

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides

Doi:10.1016/j.bmcl.2008.07.041
(2008)
Doi:10.1246/bcsj.35.1245
(1962)
Total Synthesis of (-)-Chorismic Acid and (-)-Shikimic Acid

Doi:10.1021/jo00385a022
(1987)
Condition Screening for Sustainable Catalysis in Single-Electron Steps by Cyclic Voltammetry: Additives and Solvents

Doi:10.1002/cssc.201900344
(2019)
Heteroarylnitrones as drugs for neurodegenerative diseases: Synthesis, neuroprotective properties, and free radical scavenger properties

Doi:10.1021/jm8006432
(2008)
Stereospecific total synthesis of somocystinamide A

Doi:10.1021/ol8016947
(2008)

Article Doi