Folate Analogues as Inhibitors of Thymidylate Synthase

DOI: 10.1021/jm00387a016

Source and publish data:

Journal of Medicinal Chemistry p. 675 - 678 (1987)

Update date:2022-07-29

Topics:

Authors:

Brixner, Diana I.

Ueda, Takamori

Cheng, Yung-Chi

Hynes, John B.

Broom, Arthur D.

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Article abstract of DOI:10.1021/jm00387a016

Recent demonstrations that deazafolate analogues may act as potent inhibitors of thymidylate synthase (TS) provided a firm rationale for the synthesis of N¹⁰-propargyl derivatives of 8-deazafolate (3) and 8-deazaaminopterin (4).A complete assig

Full text of DOI:10.1021/jm00387a016

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