THE SYNTHESIS OF (+)- AND (-)-1-(1-ISOQUINOLINYL)-1-(2-PYRIDYL)ETHANOL. A CHIRAL LIGAND WITH USEFUL CHELATING PROPERTIES.

Article abstract of DOI:10.1016/S0040-4020(01)87421-4

(+/-)-1-(1-isoquinolinyl)-1-(2-pyridyl)ethanol has been prepared and the two enantiomers have been resolved by derivatization with a chiral isocyanate followed by a chromatographic separation.The relative configurations of the diastereomers are discussed in relation to their chromatographic behaviour and NMR spectral data.The enantiomeric alcohols obtained after hydrolysis of the diastereomeric carbamates can be alkylated or attached to a Merrifield resin to afford useful chiral chelating ligands for transition metals.