Synthesis of Deoxyfrenolicin and Nanaomycin A

DOI: 10.1021/jo00383a018

Source and publish data:

Journal of Organic Chemistry p. 1273 - 1276 (1987)

Update date:2022-08-03

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Authors:

Kraus, George A.

Molina, Maria Teresa

Walling, John A.

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Article abstract of DOI:10.1021/jo00383a018

Deoxyfrenolicin and nanaomycin A have been synthesized.Key steps in the synthesis include a phtalide annulation reaction to produce a naphthoquinone, a tandem Diels-Alder/retro-Claisen reaction to produce the carbon skeleton, and a stereoselective reduction of a hemiketal.

Full text of DOI:10.1021/jo00383a018

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