Asymmetric synthesis of diastereomerically and enantiomerically pure α-amino-γ-nitro carboxylic esters via Michael addition of the titanated bislactim ether of cyclo (-L-Val-Gly-) to nitroolefines

Article abstract of DOI:10.1016/0040-4020(92)80011-4

The titanated bislactim ethers of cyclo(-L-Val-Gly-) 3 and 7 were added highly diastereoselectively in a 1,4-fashion to the nitro olefines 4 yielding the nitro compounds 5. Upon acidic hydrolysis these nitro compounds 5 afforded the α-amino-γ-nitro acid e