Stereocontrolled synthesis of nucleoside-methylphosphonate-methyl ester diastereomers from mixed anhydride

Article abstract of DOI:10.1016/0040-4039(96)00974-4

Nucleoside-3'-methylphosphonate was converted to a diastereomeic mixture of di-n-butylphosphiothioic anhydride and the stereoisomers were separated. Activation of each isomer with silver nitrate and coupling with methanol resulted in the formation of a methyl ester with inversion of configuration.