Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy

DOI: 10.1021/jm9015334

Source and publish data:

Journal of Medicinal Chemistry p. 7946 - 7949 (2009)

Update date:2022-07-29

Topics:

Authors:

Verhoest, Patrick R.

Proulx-Lafrance, Caroline

Corman, Michael

Chenard, Lois

Helal, Christopher J.

Hou, Xinjun

Kleiman, Robin

Liu, Shenping

Marr, Eric

Menniti, Frank S.

Schmidt, Christopher J.

Vanase-Frawley, Michelle

Schmidt, Anne W.

Williams, Robert D.

Nelson, Frederick R.

Fonseca, Kari R.

Liras, Spiros

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Article abstract of DOI:10.1021/jm9015334

By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.

Full text of DOI:10.1021/jm9015334

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