Organic Letters p. 5153 - 5157 (2021)
Update date:2022-08-03
Topics:
Yang, Dan
Wu, Xiong
Zheng, Xiao-Jie
Xie, Jian-Hua
Zhou, Qi-Lin
An efficient asymmetric hydrogenation of racemic I-substituted cyclic β-ketoesters via dynamic kinetic resolution to provide chiral cyclic β-hydroxy esters with three contiguous stereocenters is reported. Using a chiral spiro iridium catalyst (R)-5 (Ir-SpiroSAP), a series of racemic I-Aryl/alkyl substituted cyclic β-ketoesters were hydrogenated to the corresponding chiral cyclic β-hydroxy esters in high yields (84-97%) with good to excellent enantioselectivities (69->99% ee) and cis,cis-selectivities (up to >99:1).
View MoreContact:86-791-86629460
Address:1-6F, 118 Xinzhou road, Nanchang, Jiangxi, China
Contact:+86-571-86217390
Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.
Contact:86-10-62983737; +86-10-51287608
Address:4/F Building C, 2 Shangdi Xinxi Road
Contact:+86 512 6287 2180
Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
Fuxin Jintelai Fluorin Chemical Co., Ltd.
Contact:+86-0418-8229599
Address:, 7th Huagong Road, Fluorine industry development zone (Yimatu Town,Fumeng County),Fuxin City, Liaoning Province, China
Doi:10.1039/c5cc08747c
(2016)Doi:10.1016/S0040-4039(00)84869-8
(1986)Doi:10.1016/S0031-9422(00)82345-6
(1987)Doi:10.1021/ja01508a052
(1960)Doi:10.1016/j.bmcl.2010.04.055
(2010)Doi:10.1016/S0040-4020(01)88178-3
(1986)