Synthesis p. 857 - 859 (1986)
Update date:2022-07-29
Topics:
Kinoshita, Toshio
Kondo, Masaya
Tanaka, Hirokazu
Furukawa, Sunao
5,5'-Methylenebis<1,3-disubstituted 6-methyl-2,4(1H,3H)-pyrimidinedione> derivatives were obtained in excellent yield by the reaction of 1,3-disubstituted 6-methyl-2,4(1H,3H)-pyrimidinedione with paraformaldehyde under acidic conditions (25, 50, and 100percent formic acid, 0.5 N hydrochloric acid, and trifluoroacetic acid).When acetic acid was used as acidic solvent, hydroxymethylation occurred predominantly, giving 5-acetoxymethyl-1,3,6-trimethyl-2,4(1H,3H)-pyrimidinedione.
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Doi:10.1021/ja8062887
(2008)Doi:10.1021/acs.jafc.9b02819
(2019)Doi:10.1021/jm800913d
(2008)Doi:10.1246/cl.1986.1719
(1986)Doi:10.1016/S0040-4039(00)85212-0
(1986)Doi:10.1002/ardp.19432811003
(1943)
