An Efficient One-Pot Synthesis of N-Protected α-Amino-β-dialkoxyphosphinyloxy(diphenoxyphosphinyloxy)-carboxylic Acids (Phosphate-Group Esters of O-Phosphorylated N-Protected α-Amino-β-hydroxyamino Acids)

Article abstract of DOI:10.1055/s-1986-31710

Dialkyl or diphenyl phosphorochloridites readily phosphitylate N-Boc- and N-Z-serine in the presence of pyridine to give N-protected O,O'-disubstituted phosphoserines in high yields after iodine/water oxidation.This procedure was also extended to the preparation of N-protected O,O'-disubstituted phosphothreonines and N-protected O,O'-disubstituted phosphotyrosines.