Synthesis p. 1041 - 1044 (1986)
Update date:2022-09-26
Topics:
Winckelmann, Ib
Larsen, Erik H.
A convenient one-pot procedure for the synthesis of 1-substituted and 1,3-disubstituted uracils and 2-thiouracils consists of acylation of ureas or thioureas with methyl 3,3-dimethoxypropanoate in the presence of a strong base, and acidic work-up.The yields range from 36 to 99percent.In all cases, only one regioisomer is isolated.
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Doi:10.1021/ja01551a049
(1958)Doi:10.1039/P29860001687
(1986)Doi:10.1021/om00153a027
(1987)Doi:10.1039/b811581h
(2008)Doi:10.1007/BF00953343
(1986)Doi:10.1016/j.tet.2008.10.026
(2008)
