SYNTHESIS OF UNSYMMETRICAL SPERMINE ALKALOIDS OF THE HOMALIUM GROUP

DOI: 10.1016/S0040-4039(00)85156-4

Source and publish data:

Tetrahedron Letters p. 5147 - 5150 (1986)

Update date:2022-08-04

Topics: Synthesis Chromatography Purification Spectroscopy Extraction Chemical Reaction Alkaloids Spermine Unsymmetrical

Authors:

Crombie, Leslie

Jones, Raymond C. F.

Haigh, David

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Article abstract of DOI:10.1016/S0040-4039(00)85156-4

Spermine alkaloids homaline, hopromalinol, hopromine, and hoprominol are prepared by sequential coupling of 4-substituted 5-methyl-1,5-diazacyclooctan-2-ones, available by transamidation from 4-substituted azetidin-2-ones, to 1,4-dichlorobut-2-ene.

Full text of DOI:10.1016/S0040-4039(00)85156-4

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