Synthesis and incorporation of pyrrole carboxamide nucleoside triphosphates by DNA polymerases

Article abstract of DOI:10.1080/15257770008045449

We have synthesised and examined the enzymatic incorporation properties of the 5′-triphosphates of 2′-deoxyribosyl pyrrole 3-monocarboxamide (dMTP) and 2′-deoxyribosyl pyrrole 3,4-dicarboxamide (dDTP). These analogues we had hoped would behave as ambivale

Full text of DOI:10.1080/15257770008045449

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Nucleosides, Nucleotides and Nucleic
Acids
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Synthesis and Incorporation of Pyrrole
Carboxamide Nucleoside Triphosphates
by DNA Polymerases
D. Loakes a , M. J. Guo a e , D. M. Brown a , S. A. Salisbury b , C. L.
Smith c , I. Felix c , S. Kumar d & S. Nampalli d
a Medical Research Council, Laboratory of Molecular Biology , Hills
Road, Cambridge, CB2 2QH, UK
b Cambridge Crystallographic Data Centre , 12 Union Road,
Cambridge, CB2 1EZ, UK
c Nycomed Amersham plc, Amersham Laboratories , White Lion
Road, Amersham, Buckinghamshire, HP7 9LL, UK
d Amersham Pharmacia Biotech , 800 Centennial Ave., Piscataway,
NJ, USA
e ArQule Inc , 19 Presidential Way, Woburn, MA, 01801, USA
Published online: 17 Apr 2008.
To cite this article: D. Loakes , M. J. Guo , D. M. Brown , S. A. Salisbury , C. L. Smith , I. Felix ,
S. Kumar & S. Nampalli (2000) Synthesis and Incorporation of Pyrrole Carboxamide Nucleoside
Triphosphates by DNA Polymerases, Nucleosides, Nucleotides and Nucleic Acids, 19:10-12, 1599-1614,
DOI: 10.1080/15257770008045449
To link to this article: http://dx.doi.org/10.1080/15257770008045449
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