Carbon Dioxide: A Reagent for the Simultaneous Protection of Nucleophilic Centres and the Activation of Alternative Locations to Electrophilic Attack. Part 8. A Novel Synthetic Route to 4-Substituted-2-pyridones

Article abstract of DOI:10.1016/S0040-4020(01)86820-4

2-Pyridone, using the one-pot protection method, is lithiated specifically in the 4-position.In this way, a range of 4-substituted 2-pyridones was prepared.Their orientation of substitution was proved by X-ray analysis.