SYNTHESIS OF 2S,4S,5S-DIHYDROXYPIPECOLIC ACID AND BULGECININE FROM D-GLUCURONOLACTONE; A STRATEGY FOR THE SYNTHESIS OF 2S,4S-4-HYDROXY-α-AMINO ACIDS

Article abstract of DOI:10.1016/S0040-4020(01)89973-7

The efficient synthesis of 4S,5S-2-(N-benzyloxycarbonyl)amino-5,6-dihydrohex-2-en-4-olide (4) from D-glucuronolactone is described; the potential of (4) as a divergent intermediate for the synthesis of 2S,4S-4-hydroxy-α-amino acids is illustrated by the c